I-Mu-conotoxin CnIlIC, ekwaziwa njenge-conotoxin CnIlIC, yi-peptide eyenzeka ngokwendalo ekhoyo kwityhefu yenkumba yaselwandle i-Conus conus.Le peptide ifumene ingqwalasela enkulu kule minyaka idlulileyo kwizicelo zayo ezinokubakho kwizithambiso.I-Mu-conotoxin CnIlIC ifundelwe iziphumo zayo ezibalulekileyo eluswini, kwaye amandla ayo ekuxutyweni kwezithambiso kuhlolwa amandla ayo okuphucula.
ukubonakala kwesikhumba kunye nokuchasana nokuguga.
Ukusetyenziswa kwe-Mu-conotoxin CnIlIC kwi-cosmetics kugxininise kwikhono layo lokunciphisa ukubonakala kwemigca emihle kunye nemibimbi, ukuphucula ukuthungwa kwesikhumba, kunye nokukhuthaza ulutsha oluncinci kunye nokukhanya.Le peptide isebenza ngokujolisa i-receptors ethile eluswini, ekugqibeleni ibangela ukuba izihlunu zobuso ziphumle kwaye zinciphise ukuncipha kwemisipha ekhokelela ekubunjweni kwemibimbi.
Enye yeenzuzo eziphambili ze-Mu-conotoxin CnIlIC kukukwazi kwayo ukusebenza njengento yokuthomalalisa izihlunu xa isetyenziswe phezulu.Ngokuthintela ukukhutshwa kwe-acetylcholine kwi-neuromuscular junction, le peptide inciphisa ngokufanelekileyo ukunyakaza okuphindaphindiweyo kwemisipha eyenza imibimbi eguquguqukayo njengeenyawo ze-crow, imigca efingiweyo, kunye nemibimbi ebunzi.Ke ngoko, ukusetyenziswa rhoqo kwe-Mu-conotoxin CnIlIC kwimixube yezithambiso kunokubangela ukugudiseka, ulusu olukhangeleka luncinci.
Ukongeza, i-Mu-conotoxin CnIlIC ibonakaliswe ukuba ikhuthaze ukuveliswa kwe-collagen kunye ne-elastin eluswini.Ezi protheni ziyimfuneko ekugcineni ukuqina kwesikhumba kunye nokuqina, kwaye ukuchithwa kwabo yinto eqhelekileyo kwinkqubo yokuguga.Ngokukhuthaza i-collagen kunye ne-elastin synthesis, i-Mu-Conotoxin CnIlIC inceda ekuphuculeni ithoni yesikhumba, ukunciphisa ukugoba, kunye nokuphucula ukuthungwa kwesikhumba ngokubanzi ukuze kubonakale ubutsha, inkangeleko ethambileyo.
Ukongeza kwiipropathi zayo zokuchasa ukuguga, i-Mu-conotoxin CnIlIC ikwanakho ukujongana nezinye iinkxalabo zolusu, ezifana ne-hyperpigmentation kunye nethoni yesikhumba engalinganiyo.Uphando lubonisa ukuba le peptide ilawula ukuveliswa kunye nokuhanjiswa kwe-melanin, okukhokelela kwithoni yesikhumba esithe kratya kunye nekhazimlayo.Ngokulawula i-pigmentation kunye nokunciphisa ukubunjwa kwamabala amnyama, i-Mu-Conotoxin CnIlIC inceda ukudala ibala elicacileyo, elikhanyayo.
Ukusetyenziswa kwe-Mu-conotoxin CnIlIC kwii-cosmetics kuvula indlela yokuphuhliswa kweemveliso zokunakekelwa kwesikhumba, ukubonelela ngezisombululo eziphambili zokutshintsha kwesikhumba ezinxulumene neminyaka.Ukusuka kwiiserum kunye neekhrimu ukuya kwiimaski kunye nonyango, iifomyula zokuthambisa eziqulathe le peptide ziyilelwe ukujolisa kwiimpawu ezininzi zokuguga kunye nokubonelela ngezibonelelo zokhathalelo olubanzi lwesikhumba.
Ngokucacileyo, ukusetyenziswa kwe-Mu-conotoxin CnIlIC kwizinto zokuthambisa kuxhaswa ngovavanyo olungqongqo kunye novavanyo lokhuseleko ukuze kuqinisekiswe ukusebenza kwayo kunye nokunyamezela.Iinkampani zokuthambisa kunye neengcali zokhathalelo lwesikhumba ziqhuba ngokuqhubekayo uphando kunye novavanyo lweklinikhi ukuphonononga ngakumbi amandla ale peptide kunye nokucokisa ukusetyenziswa kwayo ekuqulunqeni ukhathalelo lwesikhumba.
Isishwankathelo, i-Mu-conotoxin CnIlIC inamathuba abanzi kwintsimi yezithambiso, ibonelela ngendlela entsha yokujongana nokuguga kwesikhumba kunye nokuphucula umgangatho wesikhumba ngokubanzi.Njengoko uphando kunye nophuhliso kule ntsimi luqhubeka luqhubela phambili, kulindeleke ukuba iimveliso zokunakekelwa kwesikhumba ezininzi kunye ne-Mu-conotoxin CnIlIC ziya kubonakala ngenxa yeziphumo zabo ezibalulekileyo zesicelo.Ngokukwazi kwayo ukunciphisa imibimbi, ukuphucula ukuthungwa kwesikhumba kunye nokukhuthaza umbala oqaqambileyo, i-Mu-Conotoxin CnIlIC ithembisa ukutshintsha indlela esisondela ngayo ekunyamekelweni kwesikhumba esichasayo kwaye siphakamise ibha yokwakheka kwezithambiso kwiminyaka ezayo.
Ixesha lokuposa: Dec-22-2023